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. 2018 Nov 19;18(2):352–371. doi: 10.1074/mcp.RA118.001181

Fig. 9.

Fig. 9.

H. pylori up-regulates G3BP2 in gerbil gastric epithelium in vivo in a cag-dependent manner. A, G3BP2 protein expression was evaluated by immunohistochemistry in gerbil gastric tissue sections from uninfected gerbils, and gerbils infected with wild-type cag+ H. pylori strain 7.13 or its cagE-isogenic mutant. A single pathologist assessed the percentage of epithelial G3BP2+ cells and the intensity of G3BP2 staining. The immunohistochemistry (IHC) score reflects the percentage of cells positive for G3BP2, multiplied by the intensity of staining, as previously described (22). Each bar indicates the average epithelial IHC score with standard error of the mean. B, G3BP2 protein expression was evaluated in normal gerbil gastric mucosa (n = 20) or gastric mucosa with advanced lesions (n = 7, advanced), which included gastric dysplasia and adenocarcinoma. Three cases of nonatrophic gastritis were not included in these analyses. C, Representative images of G3BP2 protein expression in normal, gastritis, or dysplastic gastric tissue sections. ANOVA tests were used to determine statistical significance among groups. *, p < 0.05; **, p < 0.005.