Table 3.
Animal | Parameter | Dose (mg/kg) |
|||
---|---|---|---|---|---|
150 | 300 | 600 | control | ||
U (mmol/l) | 7.30 ± 0.86* | 4.66 ± 0.35 | 5.73 ± 0.71 | 4.96 ± 0.27 | |
Cr (mg/dl) | 0.7 ± 0.00 | 0.7 ± 0.00 | 0.7 ± 0.00 | 0.7 ± 0.00 | |
Na+ (mmol) | 138 ± 2.8 | 134.8 ± 0.73 | 133 ± 3.01 | 138.4 ± 2.34 | |
K+ (mmol) | 4.5 ± 0.32 | 3.96 ± 0.21 | 4.03 ± 0.31 | 3.8 ± 0.14 | |
Female | Cl− (mmol) | 95.3 ± 2.07 | 89.8 ± 1.56* | 95.00 ± 1.91 | 97.2 ± 1.36 |
HCO3- (mmol) | 21.67 ± 0.52 | 23.6 ± 1.51 | 24.00 ± 1.08 | 23.2 ± 0.66 | |
Total Protein (g/dl) | 6.33 ± 0.07 | 6.68 ± 0.18 | 6.43 ± 0.17 | 6.12 ± 0.44 | |
Albumin (g/dl) | 3.00 ± 0.04 | 2.84 ± 0.11 | 2.80 ± 0.09 | 2.66 ± 0.19 | |
AST (U/L) | 177.33 ± 5.47 | 169.6 ± 17.46 | 188.25 ± 3.90 | 194.2 ± 5.44 | |
ALT (U/L) | 54.0 ± 10.11 | 47.4 ± 1.94 | 67 ± 3.61* | 49.4 ± 1.78 | |
T. Bilirubin (mg/dl) | 0.45 ± 0.11 | 1.156 ± 0.51 | 0.73 ± 0.05 | 0.582 ± 1.55 | |
D. Bilirubin (mg/dl) | 0.10 ± 0.02 | 0.184 ± 0.06 | 0.20 ± 0.02* | 0.112 ± 0.03 | |
U (mmol/l) | 3.44 ± 0.54 | 4.90 ± 0.06* | 3.53 ± 0.75 | 2.80 ± 0.26 | |
Cr (mg/dl) | 0.82 ± 0.05 | 0.78 ± 0.05 | 0.85 ± 0.10 | 0.66 ± 0.06 | |
Na+ (mmol) | 142.60 ± 0.87 | 142.00 ± 0.55 | 143.75 ± 0.85 | 144.40 ± 1.07 | |
K+ (mmol) | 5.00 ± 0.03 | 5.00 ± 0.10 | 4.55 ± 0.26 | 5.00 ± 0.05 | |
Male | Cl− (mmol) | 101.80 ± 0.92 | 102.50 ± 1.17 | 102.50 ± 1.44 | 105.80 ± 1.53 |
HCO3- (mmol) | 25.00 ± 1.52 | 24.20 ± 0.86* | 26.00 ± 1.47 | 27.00 ± 0.84 | |
Total Protein (g/dl) | 5.80 ± 0.11 | 5.78 ± 0.17 | 5.63 ± 0.23 | 6.06 ± 0.24 | |
Albumin (g/dl) | 3.12 ± 0.19 | 3.22 ± 0.07 | 3.00 ± 0.17 | 3.20 ± 0.12 | |
AST (U/L) | 235.20 ± 6.66* | 238.40 ± 18.43 | 257.75 ± 12.48* | 203.00 ± 10.41 | |
ALT (U/L) | 65.40 ± 19.26 | 68.40 ± 3.23 | 117.56 ± 11.26* | 79.60 ± 5.49 | |
T. Bilirubin (mg/dl) | 0.33 ± 0.08 | 0.76 ± 0.22 | 0.78 ± 0.20 | 0.50 ± 0.12 | |
D. Bilirubin (mg/dl) | 0.09 ± 0.03 | 0.11 ± 0.02 | 0.08 ± 0.02 | 0.10 ± 0.02 |
Data presented as Mean ± S.E.M. *p < 0.05; U= Urea, Cr= Creatinine, aspartate aminotransferase (AST), alanine amino transferase (ALT), T. = Total, C. = Conjugated, D. = Direct.