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Myonuclei are acquired during hypertrophy but not lost during atrophy in mouse. Micrographs of same EDL muscle fiber over time following the induction of hypertrophy (top row) and the subsequent induction of atrophy (bottom row). Fluorescently labeled oligonucleotides were used to visualize the nuclei in vivo. The dotted lines represent the sarcolemma. Scale bar = 50 μm. (Adapted from Bruusgaard et al., 2010. Used by permission of the Proceedings of the National Academy of Sciences.)
