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. 2019 Jan 16;9(2):374–383. doi: 10.1002/2211-5463.12581

Figure 2.

Figure 2

miRNA‐206 specifically downregulates BDNF mRNA with a long 3′ UTR. (A) Dual‐luciferase assays showed a significant reduction in the luciferase activities of vectors fused to a long 3′ UTR by miRNA‐206. *P < 0.05 by one‐way ANOVA with Bonferroni post‐hoc comparisons. Error bars represent the SD (n = 3). (B) miRNA‐206 failed to affect the luciferase activity of vectors fused to a short 3′ UTR. One‐way ANOVA with Bonferroni post‐hoc comparisons. Error bars represent the SD (n = 3). (C) Transfection of miRNA‐206 reduced the luciferase activities of vectors containing #3 target site but failed when the seed sequences of the #3 sites were mutated, revealing the target specificity. **P < 0.01 by Student's t‐test, Error bars represent the SD (n = 4).