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. 2019 Jan 4;11(1):40. doi: 10.3390/cancers11010040

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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DCs matured with a two-step protocol in the presence of anti-CD40 and anti-IL10R antibodies for 24 h, followed by LPS/IFNγ/CpG stimuli prolong animal survival in a vaccination mouse model of ovarian cancer. (A) Vaccination scheme: mice were inoculated i.p. with ID8 cells at day 0, followed by i.p. vaccination with the indicated DC formulations (pulsed with an ID8 tumor cell lysate treated with squaric acid (LSQ) or kept unpulsed (Unp)) at day 7, 14 and 21 (n ≥ 5 for each group). (B,C) Body weight and animal survival were evaluated and plotted in Kaplan–Meier cumulative survival plots. Student’s t test results (comparing GM15-2 step DCs (LSQ) to both GM4-1 step DCs (LSQ) and placebo) is indicated with an asterisk: * p < 0.05. (CpG: CpG oligonucleotides; DC: dendritic cells; IFN-γ: interferon-γ; LPS: lipopolysaccharide).

DCs matured with a two-step protocol in the presence of anti-CD40 and anti-IL10R antibodies for 24 h, followed by LPS/IFNγ/CpG stimuli prolong animal survival in a vaccination mouse model of ovarian cancer. (A) Vaccination scheme: mice were inoculated i.p. with ID8 cells at day 0, followed by i.p. vaccination with the indicated DC formulations (pulsed with an ID8 tumor cell lysate treated with squaric acid (LSQ) or kept unpulsed (Unp)) at day 7, 14 and 21 (n ≥ 5 for each group). (B,C) Body weight and animal survival were evaluated and plotted in Kaplan–Meier cumulative survival plots. Student’s t test results (comparing GM15-2 step DCs (LSQ) to both GM4-1 step DCs (LSQ) and placebo) is indicated with an asterisk: * p < 0.05. (CpG: CpG oligonucleotides; DC: dendritic cells; IFN-γ: interferon-γ; LPS: lipopolysaccharide).