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. 2019 Jan 4;11(1):40. doi: 10.3390/cancers11010040

Figure 6.

Figure 6

Figure 6

Blocking the prostaglandin E2 pathway during DC differentiation and maturation prolongs animal survival in a vaccination mouse model of ovarian cancer. (A–C) Mice were inoculated i.p. with ID8-fast cells at day 0, followed by i.p. vaccination with the indicated DC formulations at day 7, 14 and 21 (n ≥ 5 for each group). Body weight and animal survival were evaluated and plotted in Kaplan–Meier cumulative survival plots. Student’s t test results (comparing DC5 LSQ DCs to both GM15-2 step LSQ and classical GM4-1 step LSQ DCs) are indicated with an asterisk: ** p < 0.01 (D) Animals were vaccinated as reported above; T cells were then isolated from inguinal LN on day 28 post tumor inoculation and injected in the tail vein of recipient mice 3 days before tumor challenge with i.p. injection of ID8 fast cells. Body weight and animal survival were evaluated and plotted in Kaplan–Meier cumulative survival plots. Student’s t test results are indicated with an asterisk: ** p < 0.01. (DC: dendritic cells).