Table 2.
Pro-apoptotic compounds isolated from marine sponges.
| Compound | Mitochondrial Pathway | Death Receptor Pathway | Caspases Activation | Other Pathways |
|---|---|---|---|---|
| Alkaloids | ||||
| Aaptamine | NFκB/AP-1 | |||
| Isoaptamine | 3 and 7 | |||
| Crambescidin 800 | 3 | |||
| Fascaplysin | 3 | AKT/AMPK | ||
| Lamellarin D | ✔ | |||
| Makulavamines | 3, 8 and 9 | |||
| Manzamine A | ✔ | 9 | ||
| Monanchocidin A | 3 and 7 | |||
| Renieramycin M | 3 and 7 | |||
| Nortopsentins A-C | ✔ | |||
| Terpenoids | ||||
| 10-Acetylirciformonin B | 3, 8 and 9 | |||
| Heteronemin | ✔ | ✔ | 3, 8, 9 and 10 | |
| Stellettins A and B | ✔ | 8 | ||
| Smenospongine | p38/AMPK | |||
| Macrolides | ||||
| Peloruside A | 3 and 7 | |||
| Salarins | ✔ | 3 and 9 | ||
| Tedanolides | 3 and 12 | |||
| Others | ||||
| Agelasine B | ✔ | 8 | Bcl-2 | |
| Dideoxypetrosynol A | ✔ | 3 and 9 | BAX/Bcl-2 | |
| Jasplakinolide | 3 | BAX/Bcl-2 | ||
| Psammaplysene A | ✔ | FOXO1 |