Table 4.
Classification of the genes that were found to be differentially expressed for patient populations with >0.01% clonogenic cells. The upregulated genes are associated with cell cycle and signaling, whereas the downregulated genes mostly are linked with metabolism. For details on the encoded proteins, see Supplementary Table S6.
| Classification Based on Protein Function | Gene Expression in AML Population with Colony Formation | |
|---|---|---|
| Upregulated | Downregulated | |
| Cell cycle, mitosis | KIAA1383/MTR120; LMLN; PARD6A; GRB10 | |
| Transcription | (RPS4Y1) | |
| Apoptosis | C3orf38? | |
| Chaperone | HSPA12A | |
| Signaling, transport | APOL1; GRB10; PPADDC3/PLPP7 | P2XR4; TMLHE |
| Metabolism | NUDT19; TMLHE | |
| Unknown | LOC642082; LOC648605 | |