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. 2019 Jan 18;10(1):67. doi: 10.3390/genes10010067

Figure 1.

Figure 1

Schematic representation of sites of monoubiquitination at lysines (K) on histone tails protruding from the core octamer structure of nucleosomes. Monoubiquitination at K34 and K120 on histone H2B, as well as at K31 on histone H4, has been associated with transcriptional elongation. Monoubiquitination of K119 on histone H2A is written by an E3 ligase in polycomb repressor complex 1 and is associated with inactive chromatin. K13 and K15 on the histone H2A tail are written by E3 ligases associated with DNA damage. K127 and K129 on histone tail H2A are ubiquitinated by E3 ligase activity of the Breast Cancer 1 (BRCA1)- BRCA1-Associated RING Domain Protein 1 (BARD1) complex. It is unclear whether K125 is monoubiquitinated in vivo. Monoubiquitination at K31 on histone H4, as well as at K34 and K120 on histone H2A, participates in histone crosstalk to promote the methylation of K4 and K79 on histone H3. Ub: Ubiquitin.