Table 1.
Sites of histone ubiquitination and the E3 ligases responsible for writing them.
| Histone Modification | E3 Ligases Participating in Histone Monoubiquitination |
|---|---|
| Histone H2B: | |
| H2B K120ub1 (H2Bub1) | RNF20-RNF40, MDM2, BRCA1-BARD1, BAF250B |
| H2B K34ub1 | MSL2 |
| Histone H2A: | |
| H2A K119ub1 | Polycomb repressor complex 1 (RING1A-RING1B-BMI1), |
| CRLB4, TRIM37, LASU1, MDM2, 2A-HUB/hRUL138 | |
| H2A K13ub1, K15ub1 | RNF8, RNF168 |
| H2A K127ub, K129ub | BRCA1-BARD1 |
| Histone H2A.Z: | |
| H2A.Z K120ub, K121ub | RING1B |
| Histone H2AX: | |
| H2AX K119ub1 | RING1B-BMI1 |
| H2AX K13ub1, K15ub1 | RNF8, RNF168 |
| H2AX K127ub, K129ub | BRCA1-BARD1 |
| Histone H4: | |
| H4 K31ub1 | CUL4A |
RNF20-RNF40: Ring Finger Protein 20 - 40; MDM2: Mouse Double Minute 2; BRCA1-BARD1: Breast Cancer 1 – BRCA1- Associated RING Domain Protein 1; BAF250B: also known as ARID1B, AT-Rich Interaction Domain 1B; MSL2: Male-Specific Lethal 2 Homolog; RING1A-RING1B-BMI1: Ring Finger 1A-Ring Finger 1B-B Lymphoma Mo-MLV Insertion Region 1 Homolog; CRLB4: Cullin4B-E3 ligase complex; TRIM37: Tripartite Motif Containing 37; LASU1: also known as E3Histone; 2A-HUB/hRUL138: H2A monoubiquitination ligase/human RNA-binding ubiquitin ligase of 138 kDa; CUL4A: Cullin 4A.