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. 2019 Jan 17;8(1):65. doi: 10.3390/cells8010065

Figure 1.

Figure 1

Induced pluripotent stem (iPS) cells derived from fibroblasts of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome patient. (A) Immunocytochemical analyses showed positive expression of pluripotency markers Lin28, Oct4, SSEA4 and Tra-1-60 on both control and MELAS iPS cells. (B) Western blots showing the expression of c-Myc, Klf4, Lin28A, Oct4, Sox2 in iPS cells. (C) Western blots showing the expression of respiratory complexes in fibroblasts and iPS cells, respectively. (D) Quantification of respiratory chain complex proteins in iPS cells represented as fold of normal. All measurements are expressed as mean values ± SEM, n = 3–5. Comparisons with the control cells were performed by the ANOVA-test. ** p < 0.01, # p < 0.001, versus control. Scale bar: 20 μm.