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. 2019 Jan 17;8(1):65. doi: 10.3390/cells8010065

Figure 5.

Figure 5

Decreased oxygen consumption rate, ATP production and cell viability. (A–D)Control cells were able to maintain uncoupled respiration at a higher oxygen consumption rate (OCR) in the presence of CCCP at different concentrations in comparison with MELAS iPS cells. (E) Intracellular content of ATP was determined in the presence or absence of CCCP. (F) MELAS iPS cells showed a significant decline in cell viability in the presence of CCCP in comparison with control iPS cells. All measurements are expressed as mean values ± SEM, n = 3–5. * p < 0.05, ** p < 0.01, # p < 0.001, versus control.