Table 4.
Spearman rank order correlations between serum cytokine concentrations in 33 participants against participants’ bone characteristics.
| Correlation Coefficient (r) | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bone Mineral Density | Bone Mineral Content | |||||||||||||||||||||
| Dominant | Non-Dominant | Dominant | Non-Dominant | |||||||||||||||||||
| Total | Thoracic | Lumbar | Pelvis | Rib | Arm | Leg | Rib | Arm | Leg | T-score | Z-score | Total | Thoracic | Lumbar | Pelvis | Rib | Arm | Leg | Rib | Arm | Leg | |
| IL-1β | 0.25 | 0.16 | 0.10 | 0.13 | 0.05 | 0.15 | 0.25 | 0.22 | 0.16 | 0.29 | 0.26 | 0.36 * | 0.27 | 0.04 | 0.16 | 0.22 | −0.24 | 0.31 | 0.33 | 0.11 | 0.25 | 0.32 |
| IL-6 | 0.22 | 0.20 | −0.02 | 0.16 | 0.03 | 0.13 | 0.19 | 0.22 | 0.17 | 0.21 | 0.24 | 0.32 | 0.25 | 0.18 | 0.01 | 0.26 | −0.15 | 0.27 | 0.24 | 0.12 | 0.26 | 0.24 |
| TNFα | 0.25 | 0.19 | 0.07 | 0.12 | 0.05 | 0.18 | 0.26 | 0.21 | 0.18 | 0.29 | 0.28 | 0.35 * | 0.32 | 0.14 | 0.17 | 0.22 | −0.07 | 0.33 | 0.39 * | 0.09 | 0.27 | 0.39 * |
| G-CSF | 0.27 | 0.05 | 0.04 | 0.19 | 0.26 | 0.07 | 0.12 | 0.21 | 0.10 | 0.20 | 0.31 | 0.29 | 0.22 | 0.26 | 0.17 | 0.23 | 0.13 | 0.11 | 0.26 | 0.18 | 0.08 | 0.26 |
| IFNg | 0.04 | −0.07 | −0.09 | −0.16 | 0.07 | 0.12 | 0.04 | 0.02 | 0.06 | 0.02 | −0.04 | 0.00 | 0.00 | −0.12 | 0.05 | −0.17 | −0.05 | −0.01 | 0.07 | 0.02 | 0.00 | 0.06 |
| IL-10 | 0.13 | 0.16 | 0.00 | 0.11 | 0.02 | 0.09 | 0.13 | 0.20 | 0.11 | 0.13 | 0.16 | 0.26 | 0.20 | 0.15 | −0.03 | 0.19 | −0.21 | 0.22 | 0.17 | 0.06 | 0.18 | 0.14 |
| TGFβ-1 | 0.02 | −0.31 | −0.06 | 0.05 | −0.05 | −0.10 | −0.12 | −0.22 | −0.06 | −0.07 | −0.04 | −0.06 | −0.22 | −0.05 | 0.04 | 0.09 | −0.08 | −0.11 | −0.14 | −0.16 | −0.05 | −0.05 |
| TGFβ-2 | 0.05 | −0.16 | 0.06 | 0.05 | −0.16 | 0.02 | −0.02 | −0.20 | 0.03 | 0.00 | −0.04 | 0.09 | −0.17 | −0.10 | 0.11 | −0.01 | 0.02 | 0.01 | −0.03 | −0.19 | 0.09 | 0.04 |
| TGFβ-3 | 0.44 * | 0.45 * | 0.25 | 0.48 ** | 0.235 | 0.55 ** | 0.46 * | 0.27 | 0.55 ** | 0.51 ** | 0.36 | 0.27 | 0.334 | 0.50 ** | 0.27 | 0.39 * | 0.60 ** | 0.41 * | 0.41 * | 0.43 * | 0.41 * | 0.47 * |
| IL-8 | 0.08 | 0.11 | −0.12 | −0.04 | −0.08 | −0.03 | 0.07 | 0.03 | 0.07 | 0.12 | 0.04 | 0.17 | 0.03 | 0.05 | −0.17 | 0.07 | −0.16 | 0.09 | 0.09 | 0.10 | 0.10 | 0.13 |
| MCP-1 | −0.13 | −0.15 | −0.26 | −0.14 | −0.29 | 0.00 | −0.09 | −0.35 * | 0.09 | −0.08 | −0.24 | −0.18 | −0.30 | −0.03 | −0.19 | −0.01 | −0.11 | −0.13 | −0.16 | −0.17 | −0.07 | −0.07 |
| MIP-1α | 0.44 * | 0.20 | 0.16 | 0.30 | 0.39 * | 0.22 | 0.32 | 0.42 * | 0.29 | 0.38 * | 0.48 ** | 0.47 ** | 0.39 * | 0.24 | 0.21 | 0.43 * | 0.09 | 0.36 * | 0.43 * | 0.34 | 0.31 | 0.42 * |
| MIP-1β | 0.31 | 0.19 | 0.15 | 0.25 | 0.19 | 0.14 | 0.19 | 0.21 | 0.18 | 0.22 | 0.29 | 0.25 | 0.20 | 0.14 | 0.19 | 0.34 | 0.10 | 0.16 | 0.25 | 0.23 | 0.24 | 0.28 |
| RANTES | −0.27 | −0.30 | −0.31 | −0.22 | −0.18 | −0.18 | −0.28 | −0.39 * | −0.14 | −0.26 | −0.31 | −0.40 * | −0.35 * | 0.02 | −0.21 | −0.18 | 0.10 | −0.31 | −0.30 | −0.12 | −0.24 | −0.22 |
Note: Significant correlations are highlighted in black box (* p < 0.05; ** p < 0.01) and trends (p < 0.1) are highlighted in grey box. Abbreviations: G-CSF= Granulocyte-colony stimulating factor; IFNg= interferon gamma; IL= interleukin; MIP= macrophage inflammatory protein; MCP-1= monocyte chemoattractant protein; TGF= transforming growth factor; TNF= tumor necrosis factor; RANTES= regulated on activation, normal T cell expressed and secreted.