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. 2019 Jan 17;11(1):75. doi: 10.3390/v11010075

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Challenge experiment. (A) Challenge assay to find the suitable strain of CCHFV: Four different isolates were assayed in IFNAR^−/− to identify the lethal strains. (B) Survival rate in the challenge assay with Ank-2 strain: the pV-N13 and pV-N13 plus pCD24 groups survived in the lethal dose challenge of the IFNAR^−/− mice. (C) Percentage of body weight: Despite the lethal challenge, the pV-N13 and pV-N13 plus pCD24 groups showed an almost stable body weight range. All of the data are shown as mean ± SD.