Table 1.
Function and evolutionary conservation of TOR complex constituents. The table lists the constituents of TORC1 and TORC2 in different species and describes their molecular function. Common factors are in green, while unique factors are in red.
| H. sapiens | S. cerevisiae | D. melanogaster | C. elegans | Function | |
|---|---|---|---|---|---|
| TORC1 | mTOR | Tor1, Tor2 | TOR1 | TOR | Serine/threonine kinase |
| TEL2, TTI1, TTI2 | Tel2, Tti1, Tti2 | Tel2, Tti1, Tti2 | clk-2 | Assembly and stability | |
| mLST8 | Lst8 | Lst8 | lst-8 | Core complex | |
| DEPTOR | - | - | - | mTOR inhibitor | |
| RAPTOR | Kog1 | Raptor | daf-15 | Localization; substrate binding | |
| FKBP12 | Fpr1 | FKBP12 | fkbp-2 | PPlase; binds rapamycin | |
| PRAS40 | - | - | - | mTOR inhibitor | |
| - | Tco89 | - | - | unknown | |
| TORC2 | mTOR | Tor2 | TOR | TOR | Serine/threonine kinase |
| TEL2, TTI1, TTI2 | Tel2, Tti1, Tti2 | Tel2, Tti1, Tti2 | clk-2 | Assembly and stability | |
| mLST8 | Lst8 | Lst8 | lst-8 | Activator of TORC2 kinase activity | |
| DEPTOR | - | - | - | mTOR inhibitor | |
| RICTOR | Avo3 | Rictor | rict-15 | Interaction with substrates; blocks FKBP12/Rapa | |
| PROTOR | Bit61, Bit2 | - | - | Increase of SGK1 activation | |
| mSIN1 | Avo1 | Sin1 | sinh-1 | Interaction with SGK1 | |
| - | Avo2 | - | - | Cytoskeleton regulation |