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Mammalian target of rapamycin (mTOR) signaling at the lysosomal surface. Under growth-promoting conditions, Rag (Ras-related GTPases) and Rheb (Ras homolog enriched in brain) GTPases activities result in the recruitment and activation of the mTORC1 complex. Loss of these inputs leads to blockade of mTORC1. TSC: Tuberous sclerosis complex; v-ATPase: vacuolar-type H+-ATPase.
