Table 2.

Origins and biological activities of the compounds that were found in cellular slime molds.

Compound	Source Organism	Biological Activities	Reference
Dictyopyrone A	D. discoideum D. rhizoposium D. longosporum	Promotion of morphogenesis & stalk cell differentiation, & inhibition of spore formation in D. discoideum	[100,101,103]
		Anti-proliferative activity in K562 cells	[101]
Dictyopyrone B	D. discoideum D. rhizoposium D. magnum D. longosporum	Promotion of morphogenesis & stalk cell differentiation, & inhibition of spore formation in D. discoideum	[100,101,103]
Dictyopyrone C	D. longosporum	Promotion of morphogenesis in D. discoideum	[100,101]
		Anti-proliferative activity in K562 cells	[101]
Dictyopyrone D	D. magnum	Promotion of morphogenesis in D. discoideum	[101]
Dihydrodictyopyrones A & C	D. firmibasis	N.D.	[29]
Dictyobispyrones B & E	D. giganteum	N.D.	[102]
Furanodictine A	D. discoideum	Promotion of NGF-induced neurite formation in PC-12 cells	[25]
Furanodictine B	D. discoideum	Induction of neurite formation in PC-12 cells	[25]
		Promotion of NGF-induced neurite formation in PC-12 cells	[25]
Dictyoglucosamine A	D. purpureum	Induction of neurite formation in PC-12 cells	[26]
Dictyoglucosamine B	D. discoideum	Induction of neurite formation in PC-12 cells	[26]
Brefelamide (& derivatives)	D. brefeldianum D. giganteum	Anti-proliferative activity in 1321N1 cells	[27,107]
		Anti-proliferative & anti-metastatic activities in A562 cells	[108]
		Inhibition of GDNF secretion in astrocytoma cells	[27,107]
		Anti-dengue viral activity	[109]
MPBD (& derivatives)	D. discoideum D. mucoroides	Promotion of cell differentiation in D. discoideum	[110]
		Anti-proliferative activity in K562 and HL-60 cells	[28]
		Antimicrobial activities vs. E. coli and B. subtilis	[111]
Monochasiol A	D. monochasioides	Inhibition of IL-2 production in Jurkat T cells	[33]
Monochasiols B–H	D. monochasioides	N.D.	[33]
AB0022A	D. purpureum	Antimicrobial activities vs. Gram-positive bacteria	[112]
Pf-1	P. filamentosum	Anti-proliferative activity in K562 and HL-60 cells	[32]
Pf-2	P. filamentosum	Stalk-cell-inducing activity in D. discoideum	[32]
Pt-1	P. tenuissimum	Anti-proliferative activity in K562 cells	[30]
Pt-2, Pt-3, Pt-4	P. tenuissimum	N.D.	[30]
Pt-5	P. tenuissimum	Anti-proliferative activity in K562 cells	[30]
Ppc-1 (& derivatives)	P. pseudo-candidum	Anti-proliferative activity in K562 and HeLa cells	[30]
		Promotion of glucose consumption in 3T3-L1 cells & mitochondrial uncoupling	[30,112]
		Inhibition of IL-2 production in Jurkat T cells	[114]
		Neuroprotective activities in vitro and in vivo	[115]
Dictyobiphenyls A & B	D. polycephalum	N.D.	[31]
Dictyoterphenyl A	D. polycephalum	Anti-proliferative activity in K562, HeLa and LM8 cells	[31]
Dictyoterphenyl B	D. polycephalum	N.D.	[31]

Footnote: N.D., not detected.