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. 2018 Dec 21;11(1):13. doi: 10.3390/cancers11010013

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Model for the effect of SAHA and 5-aza-dc on the response of TNBC cells to TAM. BC cells with different hormonal status vary in the expression pattern of DNMT1 and different HDACs. Epigenetic modifiers such as SAHA and 5-aza-dc result in (a) modifying the chromatin structure by reducing DNMT1 expression and inhibiting the activity and phosphorylation of different HDACs, (b) upregulating the expression of ERα and HER2/ERBB2 and (c) arresting the cell cycle in G1 and G2 phases and inducing apoptosis. These changes consequently increase the response of TNBC cells to TAM.