Table 1.
IC50 values of TAM, relative expression level of ERα and HER2/ERBB2 and their correlation to the sensitivity of the four cell lines to TAM.
| Cell Line | MCF7 | SkBr3 | BT549 | MDA-MB-231 |
|---|---|---|---|---|
| TAM IC50 (µM) | 6.8 ± 2.4 | 12.1 ± 0.89 | 11.9 ± 0.56 | 13.8 ± 0.1 |
| Relative ERα expression | 1.54 ± 0.02 | 0.35 ± 0.02 | 0.11 ± 0.01 | 0.11 ± 0.01 |
| Correlation | r = −0.09654, p = 0.0346 | |||
| (TAM IC50 versus Relative ERα expression) | ||||
| Relative HER2 expression | 0.23 ± 0.03 | 1.53 ± 0.02 | 0.17 ± 0.01 | 0.21 ± 0.005 |
| Correlation | r = −0.1877, p = 0.8123 | |||
| (TAM IC50 versus Relative HER2 expression) | ||||
Shown are the means ± SEM of at least three independent experiments. Indicated are the r values (Pearson’s correlation coefficient) with the corresponding p values.