Figure 2.

First network of all treatments in the strategy network meta-analysis (NMA-1). The size of each node corresponds to the number of patients who were randomly assigned to receive the given regimen. The lines connect the regimens that were directly compared in head-to-head randomized controlled trials (RCTs). The thickness of the lines corresponds to the number of RCTs. AC = adjuvant chemotherapy; NC = neoadjuvant chemotherapy; PC = perioperative chemotherapy without a taxane; PCB = perioperative chemotherapy combined with bevacizumab; PCR = perioperative chemotherapy combined with adjuvant chemoradiotherapy; PCT = taxane-based perioperative chemotherapy; S = surgery only.