Table 1.
Twenty-one genes with DMRs shared in all five father-sorted son groups of the “nutrition” and “heat” experiments.
| Gene Name (Ensembl ID) | Full Gene Name | Regulatory Region | Gene Ontology (GO) Term |
|---|---|---|---|
| Dock6 (ENSCPOG00000026620) | Dedicator of Cytokinesis 6 | CDS | Positive regulation of hydrolyze guanosine triphosphate (GTP) GTPase activity, guanyl-nucleotide exchange factor activity, small GTPase-mediated signal transduction, cytoplasm |
| Eps8l2 (ENSCPOG00000003802) | Epidermal growth factor receptor kinase substrate 8-like protein 2 | CDS | Cytoplasm, plasma membrane, protein complex, protein binding, positive regulation of GTPase activity, actin binding, extracellular exosome, Rho guanyl-nucleotide exchange factor activity, regulation of Rho protein signal transduction, actin filament binding, Rho protein signal transduction, ruffle, ruffle membrane, vesicle, Rac guanyl-nucleotide exchange factor activity, Rac protein signal transduction, positive regulation of ruffle assembly |
| Hmcn2 (ENSCPOG00000013220) | Hemicentin 2 | CDS | Calcium ion binding, protein binding, cell junction, cell cortex, response to stimulus |
| Icam5 (ENSCPOG00000000999) | Intercellular adhesion molecule 5 | CDS | Plasma membrane, integral component of plasma membrane, protein binding, single organismal cell-cell adhesion cell adhesion, phagocytosis, integrin binding |
| Kcns1 (ENSCPOG00000013646) | Potassium voltage-gated channel subfamily S member 1 | CDS | Transmembrane transport, protein homo-oligomerization, perinuclear region of cytoplasm, protein binding, membrane voltage-gated potassium channel complex, potassium ion transmembrane transport, potassium ion transport, ion transport, ion channel activity, delayed rectifier potassium channel activity, regulation of delayed rectifier potassium channel activity, potassium channel regulator activity |
| Klhl10 (ENSCPOG00000002818) | Kelch-Like Family Member 10, Testicular Tissue Protein Li 104 | CDS | Cytoplasm, homeostasis of number of cells within a tissue, protein binding, ubiquitin-protein transferase activity, protein ubiquitination, spermatid development, Cul3-RING ubiquitin ligase complex, cell morphogenesis, male gonad development, fertilization, male genitalia morphogenesis |
| Map3k6 (ENSCPOG00000012359) | Mitogen-Activated Protein Kinase 6 | CDS | Protein kinase activity, ATP binding, protein phosphorylation, MAP kinase, kinase activity, activation of MAPKK activity, magnesium ion binding |
| Mmp9 (ENSCPOG00000007559) | Matrix Metallopeptidase 9 | CDS | Proteolysis, metalloendopeptidase activity, ossification, collagen catabolic process, leukocyte migration |
| Myh14 (ENSCPOG00000002223) | Myosin-14 | CDS | ATP binding, metabolic process, protein binding, actin filament binding, sensory perception of sound, calmodulin binding, actomyosin structure organization, neuronal action potential, axon, motor activity, myosin complex, regulation of cell shape, stress fiber, skeletal muscle tissue development, vocalization behavior, skeletal muscle contraction, mitochondrion morphogenesis, actin-dependent ATPase activity, actin filament-based movement, microfilament motor activity, actomyosin, myosin filament |
| Notch4 (ENSCPOG00000000591) | Neurogenic locus notch homolog 4 | CDS | Integral component of membrane, calcium ion binding, protein binding, multicellular organismal development, cell differentiation, Notch signaling pathway, regulation of developmental process, mammary gland development, endothelial cell differentiation, endothelial cell morphogenesis |
| Otud6a (ENSCPOG00000012916) | OTU domain containing 6 | CDS | Skeletal system morphogenesis |
| Pclo (ENSCPOG00000009376) | Piccolo Presynaptic Cytomatrix Protein | CDS | Calcium ion binding, intracellular, metal ion binding, protein binding, cell junction, presynaptic active zone, synapse assembly, cytoskeleton organization, insulin secretion, extracellular exosome, calcium-dependent phospholipid binding, regulation of exocytosis, synapse, postsynaptic density, cAMP-mediated signaling, profilin binding, synaptic vesicle targeting |
| Plekhh3 (ENSCPOG00000010080) | Pleckstrin Homology, MyTH4 And FERM Domain Containing H3 | CDS | Signal transduction, cytoskeleton |
| Sh3gl1 (ENSCPOG00000023236) | SH3 Domain Containing GRB2 Like 1, Endophilin A2 | CDS | Cytoplasm, protein binding, cell junction, early endosome, membrane, identical protein binding, lipid binding, endocytosis, podosome, cell projection, phosphatase binding, GTPase binding |
| Sigirr (ENSCPOG00000025549) | Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain | CDS | Integral component of membrane, signal transduction, protein binding, membrane, negative regulation of cytokine-mediated signaling pathway, acute-phase response, negative regulation of sequence-specific DNA binding transcription factor activity, negative regulation of chemokine biosynthetic process |
| Slc46a2 (ENSCPOG00000001823) | Solute Carrier Family 46 Member 2 | CDS | Integral component of membrane, transmembrane transport, molecular function, plasma membrane, cell surface, transporter activity, T cell homeostasis, regulation of T cell differentiation, negative regulation of T cell apoptotic process, thymus development |
| Sox13 (ENSCPOG00000006604) | CDS | Nucleus, regulation of transcription, DNA-templated, sequence-specific DNA binding | |
| Med26 (ENSCPOG00000008968) | Mediator complex subunit 26 (adopted from mouse) | CDS | Nucleus, DNA binding, transcription, DNA-templated, regulation of transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, nucleoplasm RNA polymerase II transcription cofactor activity, mediator complex, transcription coactivator activity |
| Sncg (ENSCPOG00000023463) | Synuclein Gamma | Promoter | Cytoplasm, synaptic transmission, perinuclear region of cytoplasm, protein binding, synapse organization, extracellular exosome, microtubule organizing center, axon, neuronal cell body spindle, adult locomotory behavior, protein secretion, regulation of neurotransmitter secretion, regulation of dopamine secretion |
| Svp-1 (ENSCPOG00000025237) | Seminal vesicle polypeptide | Promoter | Copulation, DNA binding, transcription |
| Unknown (ENSCPOG00000022766) | Promoter |
DMR: DNA methylation changes; CDS: coding sequence.