Table 3.
Biological properties of O. monticola pilosulin-like peptides.
| Peptide | MIC a (μM) | Hemolytic Activity (%) | Histamine-Releasing Activity at 10 μM (%) |
|||
|---|---|---|---|---|---|---|
|
E. coli (NBRC 14237) |
S. aureus (NBRC 12732) |
S. cerevisiae (NBRC 10217) |
at 10 μM | at 50 μM | ||
| PLP1 | <3.1 | <3.1 | <50 | Negative | 32.9 | |
| PLP2 | <6.2 | <6.2 | <50 | Negative | 10.4 | 30.1 |
| PLP3 | <3.1 | <25 | <50 | Negative | 37.5 | |
| PLP4 | <3.1 | <3.1 | <3.1 | Negative | 10.5 | 66.4 |
| PLP5 | <50 | Negative | Negative | 6.9 | 94.8 | 28.3 |
| PLP6 | <3.1 | <3.1 | Negative | Negative | 33.6 | |
| Magainin | <12.5 | <25 | Negative | - | - | |
| Mastoparan | - | - | - | 13.5 b | - | 31.1 b |
| Melittin | - | - | - | 100.0 b | - | 64.3 b |
a MIC: minimum inhibitory concentration; b The activities indicate from Shigeri et al. [24]; -: not determined.