Table 1.
Summary of experimental models and results.
| Model | Effect on T-Cells | Survival | Inflam. | BALT | Prolif. | Ref. |
|---|---|---|---|---|---|---|
| CD4 T Memory to WT mice | ↑ CD4 T-memory | ++ | ++ | NA | + | [1] |
| CD4 T Memory to SCID mice | ↑ CD4 T-memory | ++/− * | ++ | 0 | +++ * | [1] |
| IL-10 Knockout mice | ↑ CD8 T-cytotoxic | ++ | ++ | + | 0 | [6] |
| CCR5−/−CXCR3−/− mice | ↑ CD8 T-memory | ++ | ++ | ++ | ++ | [7] |
| Anti-CD25 (PC61) | ↓↓ Tregs ↑ CD8 T | ++ | ++ | +++ | ++++ | [8] |
* Increase survival after clearing infection at 2 weeks, but later death from extensive proliferation. ↑ and ↓ represent increased and decreased responses, respectively.