Figure 5.

Increasing the TRPM2 expression in SH-SY5Y cell enhances H₂O₂-induced reduction in cell viability. Mean ± SEM cell viability, as a percentage of that under control conditions, in the WT and TRPM2-overexpressing (OE) cells after exposure to indicated concentrations of H₂O₂ for 24 h. The results were from three independent experiments. *, p < 0.05 and ***, p < 0.001, compared to cells without exposure to H₂O₂ in the WT or OE cells, respectively; #, p < 0.05 and ###, p < 0.001 compared between the WT and OE cells treated with the same concentration of H₂O₂.