Table 4.
Association between dietary zinc and prostate cancer by genetic susceptibility to prostate cancer, measured with tertiles of the polygenic risk score (PRS).
| ALL (n = 514) | PRS2 T1 (n = 69) | PRS2 T2 (n = 170) | PRS2 T3 (n = 275) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Co | Ca | OR a (95%CI) | Co | Ca | OR b (95%CI) | Co | Ca | OR b (95%CI) | Co | Ca | OR b (95%CI) | p-het | |
| ZINC | 0.000 | ||||||||||||
| T1 (<8.34 mg/day) | 272 | 158 | 1.00 | 94 | 30 | 1.00 | 85 | 45 | 1.00 | 93 | 83 | 1.00 | |
| T2 (8.34–10.53 mg/day) | 285 | 170 | 1.06 (0.77;1.46) | 97 | 19 | 0.68 (0.34;1.35) | 94 | 62 | 1.15 (0.68;1.93) | 94 | 89 | 1.09 (0.69;1.73) | |
| T3 (>10.53 mg/day) | 264 | 186 | 1.31 (0.88;1.95) | 81 | 20 | 0.89 (0.43;1.85) | 99 | 63 | 1.10 (0.62;1.97) | 84 | 103 | 1.50 (0.89;2.53) | |
| p-trend | 0.182 | 0.698 | 0.751 | 0.119 | |||||||||
a Odds ratio of prostate cancer adjusted by age, education, BMI, family history of prostate cancer, calcium intake and grains and legumes consumption as fixed effects, and province of residence as a random effect. b Odds ratio of prostate cancer adjusted by age, education, BMI, family history of prostate cancer, calcium intake and grains and legumes consumption as fixed effects and province of residence as a random effect, including an interaction with PRS (tertiles).