Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Modeling the radial distribution of lactate, HCO3− and H+ ions in tissues without junctional coupling, i.e., radial diffusion in extracellular spaces only. (A) Schematic representation of the 3-D spherical geometry representing a solid tumor with a hypoxic core. Results of modelling shown as radial concentration gradients at the steady-state for (B) lactate, (C) HCO3− and (D) pH in the extracellular (red) and intracellular spaces (black). Arrows indicate direction of diffusive flux.
