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Volcano plots for SpD-induced metabolic changes compared with controls (n = 3). Metabolites are considered significant if log2(fold change) > 1.2. The p-value threshold was 0.05. The significantly changed metabolites included acetate, glutamine, myo-inositol, glutathione, taurine, O-phosphocholine, and sn-Glycero-3-phosphocholine (GPC).
