Table 3.

Direction of log (FC) of metabolite-specified genes/proteins in SpD/Dox treated AC16.

Pathway	Gene	Direction of Log(FC) vs. Control			Protein
		SpD	Dox	Dox and SpD
Glutathione metabolism	TXNDC12	DOWN	DOWN	UP	Thioredoxin domain-containing protein 12
Protein digestion and absorption	COL4A1	DOWN	DOWN	UP	Collagen alpha-1(IV) chain
	COL5A2	DOWN	DOWN	UP	Collagen alpha-2(V) chain
Gap junction	MAPK3	DOWN	UP	DOWN	Mitogen-activated protein kinase
	MAP2K1	UP	DOWN	UP	Dual specificity mitogen-activated protein kinase kinase 1
Sulfur metabolism	BPNT1	DOWN	DOWN	UP	3′(2′),5′-bisphosphate nucleotidase 1
Aminoacyl-tRNA biosynthesis	FARSB	DOWN	DOWN	UP	Phenylalanine--tRNA ligase beta subunit
	TARS	UP	UP	DOWN	Threonine--tRNA ligase, cytoplasmic
Choline metabolism in cancer	MAP2K1	UP	DOWN	UP	Dual specificity mitogen-activated protein kinase kinase 1
	AKT2	DOWN	UP	UP	RAC-beta serine/threonine-protein kinase
	RAC1	DOWN	DOWN	UP	Isoform B of Ras-related C3 botulinum toxin substrate 1
	RHEB	DOWN	UP	UP	GTP-binding protein Rheb
	MAPK3	DOWN	UP	DOWN	Mitogen-activated protein kinase
Central carbon metabolism in cancer	MAP2K1	UP	DOWN	UP	Dual specificity mitogen-activated protein kinase kinase 1
	PDHB	UP	DOWN	DOWN	Isoform 2 of Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
	MTOR	UP	DOWN	UP	Serine/threonine-protein kinase mTOR
	AKT2	DOWN	UP	UP	RAC-beta serine/threonine-protein kinase
	MAPK3	DOWN	UP	DOWN	Mitogen-activated protein kinase
Long-term depression	MAP2K1	UP	DOWN	UP	Dual specificity mitogen-activated protein kinase kinase 1
	MAPK3	DOWN	UP	DOWN	Mitogen-activated protein kinase
Long-term potentiation	MAP2K1	UP	DOWN	UP	Dual specificity mitogen-activated protein kinase kinase 1
	CAMK2D	DOWN	UP	UP