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distribution of the mean methylation levels at each promoter in blood samples from the 60 controls (panel A) and 154 patients (panel B); the red, green and blue dashed lines indicate the thresholds used for the identification of hypermethylated cases obtained by adding the prefixed value of 0.15, 0.1 and 0.05 respectively to the one-sided 95% bootstrap confidence interval of the controls’ mean; the dots indicate mean methylation level of the three hypermethylated cases.
