Table 4.
Insensitivity of E. tenella complex II to classical inhibitors.
| IC50 of Succinate-cyt c Activity (μM) | ||||
|---|---|---|---|---|
| E. tenella | P. y. yoelii [39] | Rat | Porcine | |
| Atpenin A5 | >50 | 4.2 ± 0.2 [39] | 0.007 ± 0.0003 [39] | N.D. |
| Siccanin | 4.0 ± 0.6 (>50) 1 | N.D. [39] | 9.3 ± 1.0 [25] | 861 ± 822 [25] |
| Carboxin | >50 | 3.6 ± 1.0 [39] | 3.8 ± 0.1 [39] | N.D. |
| Flutolanil | >50 | >100 [39] | >100 [39] | >50 [7] |
| Stigmatellin | 78.4 ± 13.1% 2 | N.D. | N.D. | N.D. |
1 Value in parenthesis is the IC50 determined for succinate-dUQ activity. 2 Percentage inhibition at 100 nM concentration of stigmatellin, which was used as a positive control for complex III inhibition. N.D.: Not determined.