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. 2019 Jan 9;8(1):32. doi: 10.3390/cells8010032

Figure 2.

Figure 2

ADAM15 is expressed in RA synovial tissue (ST) endothelial cells (ECs). (A and B) Representative photomicrographs of STs from RA patients. (C) Representative photomicrographs of STs from OA patients. STs were stained for ADAM15. Cryosections and cultured cells were stained for ADAM15 (A, B, and D) or control IgG (C). (E) ADAM15 was increased in TNF-α-stimulated human umbilical vein endothelial cells (HUVEC)-conditioned medium compared with non-stimulated HUVEC-conditioned medium. (F) ADAM15 mRNA level was not increased by TNF, IL-1, IL-6, or interferon (IFN)-gamma stimulation (n = 3). * p < 0.05 was significant.