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. 2019 Jan 9;11(1):39. doi: 10.3390/v11010039

Figure 2.

Figure 2

MERS-CoV infection induces pyroptosis in hDPP4-transgenic mice. (A–C) Transcription of NLRP3, pro-caspase-1, and pro-IL-1β in lung tissue at Day 3 post-MERS-CoV infection (n = 5–6 per group). (D) Concentration of IL-1β in serum at Day 3 post-MERS-CoV infection. Data are expressed as means ± SEM (n = 5–6 per group). * p < 0.05, ** p < 0.01 (Student’s t test with Welch’s correction). (E) Representative images of immunohistochemical staining of caspase-1 in lung tissue on Day 7 post-challenge of sham-infected and MERS-CoV-infected mice (scale bars = 100 μm).