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. 2019 Jan 9;11(1):39. doi: 10.3390/v11010039

Figure 5.

Figure 5

Blocking the C5a-C5aR1 axis reduces pyroptosis in hDPP4-transgenic mice. (A) Representative images of immunohistochemical staining of caspase-1 in lungs from PBS-treated and anti-C5aR1 Ab-treated groups on Day 7 post-challenge (scale bars = 100 μm). (B) Transcription of pro-IL-1β in lung tissues from PBS-treated and anti-C5aR1 Ab-treated groups at Day 7 post-infection (n = 4–5 per group). (C) Concentration of IL-1β in serum at Day 1 post-MERS-CoV infection. Data are expressed as means ± SEM (n = 4–5 per group). ** p < 0.01 (Student’s t test with Welch’s correction).