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Blockade of the C5a-C5aR1 axis reduces pyroptosis in hDPP4-transgenic mice. (A–C) Concentration of IFN-γ, TNF-α, and IL-6 in serum at Day 1 post-MERS-CoV infection. Data are expressed as means ± SEM (n = 4–5 per group). * p < 0.05 (Student’s t test with Welch’s correction). (D) Infiltration of the lungs and spleen by macrophages and expression of IFN-γ receptor were assessed by immunohistochemical staining 7 days after challenge (scale bars = 100 μm).
