Table 2.
FoxO role in cell response to target specific agents.
| Tumor | Drug | Mechanism of response | Ref | |
|---|---|---|---|---|
| Breast cancer | gefitinib | FoxM1 reduction and FoxO3a nuclear accumulation | Sensitivity | [78] |
| Lung cancer | gefitinib | Increased FoxO3a level | Sensitivity | [79] |
| Lung cancer | AG1478 | Up-regulation of FoxO1, FoxO3 and FoxO4 | Sensitivity | [80] |
| Breast cancer | lapatinib | Nuclear translocation of FoxO1 | Resistance | [81] |
| Gastric cancer | lapatinib | FoxO1-mediate upregulation of Met | Resistance | [82] |
| Breast cancer | trastuzumab | FoxO1 and FoxO3 down-regulation | Resistance | [83] |
| Breast cancer | trastuzumab | Increased FoxO1a level | Resistance | [84] |
| Breast cancer | tamoxifen | Nuclear localization of FoxO1 (ABCC2) | Resistance | [85] |
| Breast cancer | tamoxifen | Decreased FoxO1 levels | Resistance | [86] |