Table 2.
References of PTC-related genes in top 40 captured genes.
| Measures | Count 1 | Genes 2 |
|---|---|---|
| Degree Centrality | 32 | AGTR1 [34] ALDH1A1 [30] COL1A1 [21] COMP [25] CXCL12 [26] DCN [32] ECM1 [24] FN1 [20] ICAM1 [20] IRS1 [26] KIT [24] LCN2 [23] LRP2 [33] LRRK2 [2] MET [21] MUC1 [29] PLAU [20] SDC4 [2] SERPINA1 [21] TIMP1 [20] CD36 [31] EGR1 [38] ALDH1A3 [37] NMU [36] ANK2 [39] APOE [35] CFD [27] COL5A1 [20] LPAR5 [36] PCSK2 [28] PROS1 [2] MMRN1 [27] |
| Closeness Centrality | 20 | AGR2 [40] CITED1 [2] CRABP1 [41] KLK10 [42] KLK7 [25] S100A2 [43] SFTPB [44] SLC26A4 [30] SLC34A2 [25] TFF3 [28] TMPRSS4 [45] TPO [41] DIO1 [32] ID4 [45] PAPSS2 [39] SLC4A4 [25] ABCC3 [46] FHL1 [38] HEY2 [46] SLC26A7 [47] |
| Betweenness Centrality | 30 | ALDH1A1 [30] COL1A1 [21] CTSC [48] CXCL12 [26] DCN [32] FN1 [20] ICAM1 [20] IRS1 [26] KIT [24] LCN2 [23] LRP2 [33] LRRK2 [2] MET [22] MUC1 [29] PLAU [21] SDC4 [2] SERPINA1 [22] SLC26A4 [30] TGFA [41] TIMP1 [19] DIO2 [32] CD36 [31] ANK2 [39] APOE [35] GABBR2 [24] PCSK2 [28] SLC4A4 [25] TESC [39] EGR1 [38] NMU [36] |
| Clustering Coefficient | 18 | CCL21 [49] CLDN1 [20] CLDN10 [50] ECM1 [24] DIO1 [32] MT1G [51] CFD [27] COL13A1 [22] COL5A1 [21] CXCR7 [52] GABBR2 [24] MMRN1 [27] PROS1 [2] COL8A2 [53] LPAR5 [36] MT1F [54] MT1M [54] NMU [36] |
| Eccentricity Centrality | 22 | CLDN1 [20] CLDN10 [50] MT1G [51] COL1A1 [20] CXCL12 [26] DCN [32] ECM1 [24] FN1 [20] MET [22] PLAU [20] SDC4 [2] TIMP1 [20] SERPINA1 [22] TGFA [41] TNFRSF11B [22] ELMO1 [55] IGSF1 [55] MT1F [54] SORBS2 [39,48] COL5A1 [21] CXCR7 [52] PROS1 [2] |
| Normalized Centrality Measure | 34 | ALDH1A1 [30] CD36 [31] COL1A1 [20] COMP [25] CXCL12 [26] DCN [32] ECM1 [24] FN1 [20] ICAM1 [20] IRS1 [26] KIT [24] LCN2 [23] LRP2 [33] LRRK2 [2] MET [22] MUC1 [29] PLAU [21] SDC4 [2] SERPINA1 [22] SLC26A4 [30] TIMP1 [20] AGTR1 [34] ANK2 [39] APOE [35] CFD [27] COL5A1 [21] LPAR5 [36] PCSK2 [28] SLC4A4 [25] ADH1B [37] GNA14 [37] NMU [36] ALDH1A3 [37] EGR1 [38] |
1 Count: The number of genes that have been confirmed to be related to PTC from top 40 genes obtained by six measures. 2 Genes: Details of existing literature that described these genes to be involved in the production of PTC. DC: Degree Centrality; CC: Closeness Centrality; BC: Betweenness Centrality; CLC: Clustering Coefficient; EC: Eccentricity Centrality; NCM: Normalized Centrality Measure.