Table 3.

Gene Ontology (GO) enrichment analysis of DEGs.

DEGs	ID	Term	Count 1	Genes 2
Up-regulated	GO:0070062	extracellular exosome	53	TIMP1 FN1 APOE COMP SERPINA1 NMU ECM1 COL5A1 LCN2 COL1A1 PLAU MET
	GO:0005886	plasma membrane	50	GNA14 AGTR1 SLC4A4 IRS1 CD36 KIT LRP2 SLC26A4 ANK2
	GO:0005615	extracellular space	34	FMOD KIT DCN CXCL12 OGN CFD CD36
	GO:0005576	extracellular region	34	FMOD DCN CXCL12 OGN COL9A3 CFD MFAP4
Down-regulated	GO:0005515	protein binding	78	APOE COL1A1 COMP ECM1 FN1 ICAM1 LRRK2 MUC1 NMU PCSK2 PLAU SDC4 SERPINA1 TIMP1 MET
	GO:0070062	extracellular exosome	44	SDC4 TIMP1 APOE COMP ALDH1A3 SERPINA1 FN1 MUC1 ICAM1 ECM1 COL5A1 LCN2 LRRK2 PLAU
	GO:0005886	plasma membrane	42	SDC4 APOE ICAM1 MET LPAR5 LRRK2 PLAU
	GO:0005615	extracellular space	40	TIMP1 PCSK2 APOE COMP SERPINA1 FN1 MUC1 ICAM1 ECM1 LCN2 COL1A1 LRRK2 PLAU
	GO:0005576	extracellular region	39	TIMP1 APOE COMP SERPINA1 NMU FN1 MET ECM1 COL5A1 LCN2 COL1A1 PLAU

¹ Count: the number of genes involved in the term. ² Genes: genes in this term correspond to the top40 genes calculated using NCM.