Figure 4.

Identification of HNF4A bound sites in iPSC-derived hepatic progenitor cells. (A) Strategy used to identify direct targets of HNF4A during the formation of the hepatic lineage from iPSCs; (B) Summary of the number of targets identified by ChIP-seq analyses; (C) Example of HNF4A enriched sequences (peaks) in the Apo2 gene; (D) Distribution of HNF4A peaks relative to the transcriptional start site of the nearest known gene; (E) Consensus HNF4A binding site determined from analyses of all peaks.