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. 2019 Jan 10;11(1):32. doi: 10.3390/toxins11010032

Table 2.

Maturation process.

scFv                             VH                                                              VL                           REF.
        CDR2                  CDR3            FW1            FW3            CDR3    
C1 54
S		 56
D		 57
N		 105
M		 107
A		 110
Y		 164
S		 204
A		 208
D		 235
L		 236
I		 [25]
RU1 G G L H [23]
ER-1 G G S L T I G [22]
10F G G S L T I G T L α
10F1 G G S L T I G G T L α
10F2 G G S L N G G T L α
10F3 G G S L N G T L α
10F4 G G S L S N G G T L α
10F5 G G S L S T G G T L α
10F6 G G S L S N G T L α

α ER-1 variants generated in this work; mutation positions are shown. VH corresponds to the variable domain of antibody heavy chain and VL is the corresponding variable domain of a light chain. CDR stands for complementarity-determining region and FW means framework. scFvs indicated in bold correspond to variants derived from scFv 10F.