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View full-text article in PMC

. 2018 Dec 27;11(1):27. doi: 10.3390/cancers11010027

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TPCs mediate oncogenic Ca²⁺ signals. Emerging evidence indicates that NAADP promotes tumorigenesis by inducing EL Ca²⁺ release through TPCs. Work carried out on melanoma B16 cells suggest that NAADP is synthesized in response to VEGF stimulation. NAADP-induced Ca²⁺ signals promote tumorigenesis by stimulating migration, invasion, angiogenesis and, maybe, proliferation. The evidence that NAADP-induced local Ca²⁺ release through TPCs is amplified in a global elevation in [Ca²⁺]_i through the Ca²⁺-induced Ca²⁺ release (CICR) process is yet to be provided.