Table 1.
ATG16 interacting proteins, the binding regions, and the functions of this interactions.
| Interacting Protein | Binding Region of ATG16 | Function | References |
|---|---|---|---|
| ATG5 | N-terminal AFIM | Essential for ATG16 complex localization to PAS and ATG8/LC3 lipidation | [9,11,14,15] |
| FIP200 | Between CCD and WD40 repeat domain | Promotes the specific targeting of ATG16L1 to the isolation membrane | [34,35] |
| WIPI2b | CCD | Promotes the recruitment of ATG16 to the isolation membrane | [36] |
| TMEM166 | WD40 repeat domain | Promotes the recruitment of ATG16L1 complex to the autophagosome membrane | [37] |
| Rab33B | CCD | Transport of Golgi-derived membrane to autophagosome | [38,39,40] |
| Clathrin | N-terminal region | Transport of plasma membrane to autophagosome | [41,42,43] |
| Annexin A2 | ND | Promotes the formation of phagophore structures | [44] |
| Connexin 43 | WD40 repeat domain | Inhibits autophagosome formation | [45,46] |
| TMEM59 | WD40 repeat domain | Xenophagy | [47,48] |
| NOD1 | WD40 repeat domain | Xenophagy | [49,50] |
| NOD2 | WD40 repeat domain | Xenophagy | [47,50,51] |
| T3JAM | WD40 repeat domain | ND | [47] |
| DEDD2 | WD40 repeat domain | ND | [47] |
| Ubiquitin | WD40 repeat domain | Xenophagy | [49,52] |
| PCM1 | ND | Antigen presentation | [53] |
| Rab33A | CCD | Hormone secretion | [38,54] |
| TRIM20 | WD40 repeat domain | Autophagic degradation of inflammasome components | [55] |
| PSMD1 | N-terminal half; WD40 repeat domain |
Autophagic degradation of PSMD1 | [56] |
| PSMD2 | WD40 repeat domain | Autophagic degradation of PSMD2 | [56] |
The proteins were listed according the order of appearance in this paper. ND: not determined.