Figure 1.

Schematic representation of the human and Saccharomyces cerevisiae purine biosynthesis pathways. Features of human and yeast enzymes are listed in Table A1, Table A2 and are shown in black and pink, respectively. For human enzymes, the numerous isoforms detected for some enzymes are not presented. Ortholog identity scores were determined as described in supplementary Table A3. Grey boxes correspond to enzymes with no or unidentified orthologs between yeast and human. “ATP production” in both yeast and human cells corresponds to the different ATP production pathways such as glycolysis and the respiratory chain/ATP synthase complexes. “Nucl.” stands for the numerous human nucleotidases, such as for example the NT5 family. Abbreviations: IMP: Inosine monophosphate; PRPP: Phosphorybosyl pyrophosphate; SAMP: Succinyl-AMP; SZMP: Succinyl Amino Imidazole Carboxamide Ribonucleotide monophosphate; XMP: Xanthosine monophosphate; ZMP: Amino Imidazole CarboxAmide Ribonucleotide monophosphate.