Table A1.

List of the Saccharomyces cerevisiae purine pathway enzymes shown in Figure 1. Enzyme features were obtained from the Saccharomyces Genome Database website [62].

Protein Name	ORF Name	Enzymatic Activities
Aah1	YNL141W	Adenine deaminase
Ade1	YAR015W	Phosphoribosyl aminoimidazole succinocarboxamide synthetase
Ade12	YNL220W	Adenylosuccinate synthase
Ade13	YLR359W	Adenylosuccinate lyase
Ade16	YLR028C	AICAR transformylase and IMP cyclohydrolase
Ade17	YMR120C	AICAR transformylase and IMP cyclohydrolase
Ade2	YOR128C	Phosphoribosylaminoimidazole carboxylase
Ade4	YMR300C	Phosphoribosylpyrophosphate amidotransferase
Ade5,7	YGL234W	Aminoimidazole ribonucleotide synthetase and glycinamide ribotide synthetase
Ade6	YGR061C	Formylglycinamidine-ribonucleotide synthetase
Ade8	YDR408C	Phosphoribosyl-glycinamide transformylase
Adk1	YDR226W	Adenylate kinase
Adk2	YER170W	Adenylate kinase
Ado1	YJR105W	Adenosine kinase
Amd1	YML035C	AMP deaminase
Apt1	YML022W	Adenine phosphoribosyltransferase
Gua1	YMR217W	GMP synthase
Gud1	YDL238C	Guanine deaminase
Guk1	YDR454C	Guanylate kinase
Hpt1	YDR399W	Hypoxanthine-guanine phosphoribosyltransferase
Imd2	YHR216W	Inosine monophosphate dehydrogenase
Imd3	YLR432W	Inosine monophosphate dehydrogenase
Imd4	YML056C	Inosine monophosphate dehydrogenase
Isn1	YOR155C	Inosine monophosphate specific nucleotidase
Phm8	YER037W	GMP, UMP and CMP nucleotidase
Pnp1	YLR209C	Purine nucleoside phosphorylase
Prs1	YKL181W	PRPP synthetase subunit
Prs2	YER099C	PRPP synthetase subunit
Prs3	YHL011C	PRPP synthetase subunit
Prs4	YBL068W	PRPP synthetase subunit
Prs5	YOL061W	PRPP synthetase subunit
Rnr1	YER070W	Large subunit of ribonucleotide-diphosphate reductase
Rnr2	YJL026W	Small subunit of ribonucleotide-diphosphate reductase
Rnr3	YIL066C	Large subunit of ribonucleotide-diphosphate reductase
Rnr4	YGR180C	Small subunit of ribonucleotide-diphosphate reductase
Ynk1	YKL067W	Nucleoside diphosphate kinase