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. 2019 Jan 1;9(1):122–133.

Figure 5.

Figure 5

Cell proliferation. A: 2-hydroxyglutarate (2HG) stimulated human fibrosarcoma cell (HT-1080) proliferation beyond its baseline in a dose-dependent manner. s.d.: standard deviation. n=5 independent biological samples. B: GSK864 inhibited the proliferation of both human fibroblasts and human fibrosarcoma cells (HT-1080) in a dose-dependent manner. s.d.: standard deviation. Proliferation of human fibrosarcoma cells (HT-1080) and fibroblasts at 0.8, 1.6 and 2 μmol GSK864 concentrations were significantly lower than control (ctrl) and 0.2 and 0.4 μmol (P < 0.001; n=5 independent biological samples per group).