Table 1.
Function of ILK in different cancers
| Cancer Type | Observed Functions of ILK | Involved Pathway | References |
|---|---|---|---|
| Prostate cancer | Survival, Growth, Motility, Apoptosis | AKT | [81,92] |
| Multiple myeloma | Angiogenesis, Survival | HIF-2α-ILK | [46,93,94] |
| Colorectal cancer | EMT, Proliferation, Invasion, Chemoresistance, Migration | NF-κB/p65 | [16,17,55] |
| Pancreatic cancer | EMT, Proliferation, Migration, Invasion | MUC1-C | [11,95] |
| Glioma cells | Proliferation, Migration, Invasion, Temozolomide resistance | Caspase3, E-cadherin, NF-κB, Cyclin D1 | [14,15,96] |
| Bladder cancer | EMT, Proliferation, Morphology | ILK/PI3K/AKT | [97,98] |
| Lung cancer | EMT, Migration, Invasion, Drug resistance | MRP1, NF-κB, MMP-9 | [18,52] |
| Gastric cancer | Growth, Migration, Survival, Multidrug resistance, Cell cycle | NF-κB, ERK1/2, E-cadherin, AP-1, MMP-2/9, Cystatin B, p-AKT | [54,99,100] |
| Tongue cancer | EMT, Proliferation, Migration, Invasion | AKT, GSK3β, MMP2, MMP9 | [58] |
| Ovarian cancer | Migration, Invasion | Rac1, AKT | [101] |
| Breast tumors | Proliferation | PI3K/AKT | [102] |
| CLL | Proliferation | NF-κB | [103] |
| Thyroid cancer | EMT, Migration | AKT | [104] |
| OSCC | EMT, Growth, Metastasis, Adhesion | AKT, GSk3β | [105] |
| RCC | EMT, Migration, Invasion | Snail, Zeb-1 | [59] |
| Retinoblastoma cells | Proliferation, Cytokinesis, Mitosis, Cytoskeleton dynamics | Unknown | [43] |
| Phyllodes breast tumors | EMT, Metastasis | E-cadherin, ZEB1, β-catenin, Twist, N-cadherin, Snail, Vimentin | [106] |
CLL: Chronic Lymphocytic Leukemia; OSCC: Oral squamous cell carcinoma; RCC: Renal Cell Carcinoma.