Figure 6.

Knock-down of FAK abolishes the oncogenic role of ACP5 in CRC cells. (A, C) CCK-8 assay (A) or transwell assay (C) showed that ACP5 overexpression induced cell proliferation or invasion, which was largely abolished by siRNAs-FAK. (B, D) CCK-8 assay (B) or transwell assay (D) showed that knock-down of ACP5 could inhibit cell proliferative or invasive ability, which was largely reversed by pcDNA3.1-FAK. Results shown are the mean ± SD (*P < 0.05, **P < 0.01, ***P < 0.001) of triplicate determination from three independent experiments.