Figure 5.

Combined SHP2 and PI3K inhibition induces tumor regression. A. Growth of IGROV1-derived tumor xenograft in nude mice treated with vehicle (n = 10), BKM120 (22.5 mg/kg), SHP099 (50 mg/kg), or SHP099+BKM120 by oral gavage. Data were represented as mean ± SEM. **P < 0.01, ***P < 0.001 by one way ANOVA. B. Body weight of nude mice receiving indicated drug treatment. Mean ± SEM values were presented. C. Immunohistochemical analyses of tumor xenografts with indicated antibodies at the conclusion of indicated drug treatment. D. The indicated bar graphes show the relative fraction of cells positive in Ki67, Cleaved Caspase 3 (CC3) in 4 mm² tumor xenograft sections. Data were represented as mean ± SEM from 6 different tumor sections, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by one way ANOVA.