Table 1.
Basic patient characteristics of the studies included in the meta-analysis and the results of methodological quality assessment using the QUADAS-2 tool.
| Author, Year (Ref.) | Age * (Years Old) | Sex | QUADAS | ||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |||
| O’Rourke et al. 2017 [14] | 59.5 (45–76) | 5M/5F | |||||
| Louis et al. 2016 [15] | 7 (3–20) | 10M/9F | |||||
| Brown et al. 2015 [16] | 50 (36–57) | 1M/2F | |||||
| Feng et al. 2016 [17] | 58 (40–66) | 5M/6F | |||||
| Gargett et al. 2016 [18] | NS | NS | |||||
| Ahmed et al. 2015 [19] | 17 (7–29) | 9M/10F | |||||
| Lamers et al. 2018 [20] | NS | NS | |||||
| Beatty et al. 2013 [21] | 78 (81 and 75) | 2M | |||||
| You et al. 2016 [22] | NS | NS | |||||
| Zhang et al. 2017 [23] | 58 (48–67) | 7M/3F | |||||
| Katz et al. 2015 [24] | 57 (51–66) | 6M/2F | |||||
| Junghans et al. 2016 [25] | 61(51–75) | 5M | |||||
| Tanyi et al. 2017 [26] | 52 | 1F | |||||
| Brown et al. 2016 [27] | 50 | 1M | |||||
| Tchou et al. 2017 [28] | 55.3 (44–64) | 6F | |||||
| Hege et al. 2017 [29] | 56 | 9M/5F | |||||
| Ali et al. 2016 [30] | NS | NS | |||||
| Maus et al. 2013 [31] | NS | NS | |||||
| Thistlethwaite et al. 2017 [32] | 47.4 (36–66) | 8M/6F | |||||
| Lamers et al. 2013 [33] | 60.8 (46–74) | 8M/4F | |||||
| Weng et al. 2018 [34] | 23.3 (16–34) | 2M/1F | |||||
| Gardner et al. 2018 [35] | NS | NS | |||||
| Zhu et al. 2016 [36] | 34 (29–39) | 1M/1F | |||||
| Wang et al. 2016 [37] | 33 (13–77) | 13M/5F | |||||
| Callahan et al. 2017 [38] | (1–14) | NS | |||||
| Turtle et al. 2016 [39] | 40 (20–73) | NS | |||||
| Wei et al. 2018 [40] | 35.8 (8–57) | 10M/13F | |||||
| Wang et al. 2017 [41] | 7 (5–9) | 5M/1F | |||||
| Fry et al. 2018 [42] | 19 (7–30) | 13M/8F | |||||
| Kochenderfer et al. 2015 [43] | 51.7(30–68) | 8M/7F | |||||
| Maude et al. 2014 [44] | 14 (5–60) | 18M/12F | |||||
| Porter et al. 2015 [45] | 66 (51–78) | 12M/2F | |||||
| Ramos et al. 2017 [46] | 34.7 (20–65) | 6M/3F | |||||
| Chen et al. 2017 [47] | 26.5 (8–44) | 1M/5F | |||||
| Kochenderfer et al. 2016 [48] | 52.4 (44–66) | 8M/2F | |||||
| Wang et al. 2014 [49] | 62.4 (37–85) | 6M/1F | |||||
| Davila et al. 2014 [50] | 50(18–59) | 12M/4F | |||||
| Pan et al. 2017 [51] | 13.3 (2–68) | 32M/19F | |||||
| Fraietta et al. 2018 [52] | 62 (57–68) | 3M | |||||
| Turtle et al. 2016 [53] | 57 (22–70) | 27M/5F | |||||
| Cruz et al. 2016 [54] | 51 (9–59) | 5M/3F | |||||
| Gardner et al. 2018 [55] | 12.2 (1–25) | 23M/22F | |||||
| Hay et al. 2018 [56] | 54 (20–73) | 93M/40F | |||||
| Park et al. 2018 [57] | 44 (23–74) | NS | |||||
| Qasim et al. 2017 [58] | 13.5 † (11 † and 16 †) | 2F | |||||
| Ritchie et al. 2013 [59] | 70.6 (64–78) | 1M/3F | |||||
| Locke et al. 2017 [60] | 52.3 (29–69) | 5M/2F | |||||
| Lee et al. 2015 [61] | 14.7 (5–27) | 14M/7F | |||||
| Kalos et al. 2018 [62] | 68.7 (64–77) | 3M | |||||
| Maude et al. 2018 [63] | 11 (3–23) | NS | |||||
| Dai et al. 2015 [64] | 38.9 (15–65) | 4M/5F | |||||
| Neelapu et al. 2017 [65] | 58 (23–76) | 68M/43F | |||||
Notes: * mean and range, † month, M: male, F: female, NS: not specified. Items of modified QUADAS-2 tool used in this study: (1) Was a consecutive or random sample of patients enrolled? (2) Did the study avoid inappropriate exclusions? (3) Was the method for determining the outcomes of patients after administration described? (4) Is the reference standard likely to correctly classify the target condition? (5) Did all patients accept the treatment of CAR T cells? According to the QUADAS-2 manual, each item was assessed as “yes”, “no” or “unclear”:
| Yes | |
| No | |
| Unclear |