Table 2.

Distinct cellular effects mediated by endothelial protein C receptor (EPCR) in different cancer settings.

Cancer Cell Line/Xenograft	Mechanism	Cellular Effects
Colorectal cancer [41]	ERK/AKT-dependent signaling	Inhibition of migration
A375 melanoma cells B16F10 melanoma cells [11,48]	ERK1/2—dependent signaling	Reduction of metastatic foci by inhibition of transendothelial migration
Malignant Pleural Mesothelioma [44]	ERK/AKT-dependent signaling; BAX, BCL2 factors	Inhibition of proliferation and migration Promotion of apoptosis
MGC803 gastric cancer cells [42]	ERK1/2—dependent signaling	Increased proliferation and migration
Breast cancer cells line [43,45,49,52]	SPOCK1/testican 1-mediated signaling MAPK-signaling	Increased expression of integrins, proliferation, 3D tumor growth and cells survival Angiogenesis
Lung adenocarcinoma [50]	ERK/AKT-dependent signaling	Inhibition of apoptosis