Table 1.
Expression of key metabolic genes involved in non-alcoholic steatohepatitis (NASH). Values are expressed as relative values with the mean of control mice values set at 1. ** p < 0.01, *** p < 0.001 vs. Ctrl and $ p < 0.05, $$ p < 0.01, $$$ p < 0.001 vs. western diet (WD) (n = 9–10/group).
| Genes | Ctrl | WD | WDS1 | WDS2 |
|---|---|---|---|---|
| Uptake | ||||
| Slc2a2 | 1 ± 0.06 | 0.95 ± 0.04 | 0.79 ± 0.12 | 0.63 ± 0.10 $ |
| Cd36 | 1 ± 0.10 | 7.54 ± 0.7 *** | 6..44 ± 0.96 | 4.3 ± 1.11 $ |
| Lipogenesis | ||||
| Acc-1 | 1 ± 0.06 | 1.05 ± 0.05 | 0.89 ± 0.14 | 0.65 ± 0.15 $ |
| Scd-1 | 1 ± 0.10 | 1.99 ± 0.14 *** | 1.68 ± 0.22 | 1.15 ± 0.19 $$ |
| Srebp-1 | 1 ± 0.06 | 1.71 ± 0.11 ** | 1.30 ± 0.19 | 1.29 ± 0.17 p=0.10 |
| Dgat-1 | 1 ± 0.04 | 1.13 ± 0.06 | 0.99 ± 0.09 | 0.89 ± 0.6 $ |
| Oxidation | ||||
| Ppar-α | 1 ± 0.06 | 1.08 ± 0.05 | 0.93 ± 0.08 | 0.76 ± 0.05 $$ |
| Cpt1a | 1 ± 0.03 | 2.09 ± 0.11 *** | 1.89 ± 0.2 | 1.68 ± 0.18 p=0.15 |
| Fibrogenesis | ||||
| Col1a1 | 1 ± 0.15 | 15.56 ± 0.87 *** | 14.32 ± 1.06 | 8.10 ± 2.73 $$ |
| Timp1 | 1 ± 0.16 | 55.78 ± 3.25 *** | 61.93 ± 7.40 | 27.99 ± 9.73 $ |
| Inflammation | ||||
| Tgf-β1 | 1 ± 0.10 | 2.12 ± 0.13 *** | 1.99 ± 0.09 | 1.46 ± 0.19 $$ |
| Tlr9 | 1 ± 0.14 | 4.20 ± 0.37 *** | 4.24 ± 0.37 | 2.10 ± 0.36 $$$ |
Slc2a2: Solute carrier family 2 member 2; Cd36: Cluster of differentiation 36; Acc1: Acetyl-CoA carboxylase-1; Scd-1: Stearoyl-CoA desaturase-1; Srebp-1: Sterol regulatory element-binding protein-1; Dgat-1: Diacylglycerol O-acyltransferase-1; Ppar-α: Peroxisome proliferator-activated receptor α; Cpt1-a: Carnitine palmitoyltransferase1-a; Col1a1: Collagen type 1 α1; Timp1: Tissue inhibitor of metalloproteinase 1; Tgf-β1: Transforming growth factor β1; Tlr9: Toll-like receptor 9.